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Rufus Mark

Rufus Mark

graduated from Yale University

Title: Five day accelerated partial breast irradiation (APBI) using stereotactic body radiation therapy (SBRT) in stage 0-ii breast cancer

Biography

Biography: Rufus Mark

Abstract

Randomized trials in selected early stage breast cancer patients with upto 10 year follow-up have proven that accelerated partial breast irradiation (APBI) given via high dose rate (HDR) implant bid in five days is equivalent to whole breast external radiation therapy (XRT) given QD in 5-6 weeks in regard to breast tumor local recurrence (LR). However, complications with APBI implant in a medicare database review have been significant with 3.95% of women requiring mastectomy, 16.2% developing infections and another 16.3% experiencing non-infection complications including rib fractures, fat necrosis and breast pain. Recently, APBI using non-invasive intensity modulated radiation therapy (IMRT) or stereotactic body radiation therapy (SBRT) given QD in five fractions has been shown in another randomized trial with five year follow-up to be equivalent to QD XRT in 6 weeks, with respect to LR. IMRT/SBRT was superior in regard to acute effects, late effects and cosmesis.