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Vuka V Katic

Vuka V Katic

Human Policlinic, Serbia

Title: Giant inflammatory myofibroblastic tumor of the breast case report and review of literature

Biography

Biography: Vuka V Katic

Abstract

Introduction: Primary inflammatory myofibroblastic tumor ( IMT ) of the breast  is extremely rare lesion. Only 19 cases have been reported in the English literature. It is an unusual benign tumor that belongs to the family of the " benign spindle cell tumors of the  of the mammary". Since MFT ( myofibroblastic tumor ) may show alarming morphologic features which can  lead to misdiagnosis of malignancy, especially to  spindle cell carcinoma, we have undertaken this study:

 

Case  report: Clinical features and aim We report a case of IMT of the breast in a 56- year - old female patient who was admitted to our hospital due to a large lobulated lump in the right breast. Mammogram and ultrasound  confirmed the solid nature of the tumor, showing a well- circumscribed homogenous mobile nontender lobulated masses, covered  by thick capsula.The giant tumor, was surgically removed.

 MacroscopyThe giant tumor, 8200 gr of weight, was surgically removed. Gros  examination showed  a well  circumscribed  firm white, yellow  to grey lobular masses ( Fig. 1 ). After conservative excision, has been  no recurrence to now (  two years have passed from operation ).

 

Methods: 50 surgical biopsies, taken from our patient,were stained with HE, Van Gieson, AB - PAS and immunohistochemical ABM, by using antiboodies to EMA, Vimentin, Demin and Ki-67.

Histopathology The lesion consists of a proliferation of spindle cells with  the morphological and immunohistochemical features of myofibroblasts, arranged   in sheets and short fascicles along with  a rich  inflammatory  infiltrate comprising predominantly plasma cells, admixed with the an  inflammatory component of lymphocytes,  and eosinophyls. The hallmark of IMT is the  sgnificant  inflammtory cell component. Mitotic figures were not observed. Histopathologically, the tumor cells were positive for SM-actin, desmin and vimentin.

 

Conclusion: On the base of literature data ( Pab Med )and our experience, We have concluded the following:

I. This neoplasm has the  intermediate biological potential. II. Like neoplasm of  intermediate biological potentia it frequently  recurs and rarely metastasizesIII.Clinical physicians should regularly follow - up patients after focal resection for IMT