Breast Cancer

Biography

Biography: Wen Zhao

Abstract

Abstract: Purpose: the prognostic role of primary tumor surgery among female patients with metastatic breast cancer is controversial. We ought to investigate whether primary tumor surgery can improve the overall survival and identify a subset of patients that will benefit from primary tumor surgery.

Methods: we conducted a retrospective, population-based cohort study by analyzing the 2010-2014 Surveillance, Epidemiology, and End Results (SEER) program data. Using Kaplan-Meier curves, we investigated whether the primary tumor surgery could improve the overall survival. Analyzing the clinicopathological feathers by using Cox proportional hazards regression, we developed and validated a prediction model that predicts survival benefit in patients who undergone primary tumor surgery and identified patients that would benefit from primary tumor surgery in the non-surgery cohort.

Results: of 7217 SEER patients enrolled in our study, 3065 (32.5%) underwent breast and 4152(57.5%) did not. Patients who had surgery achieved both overall survival benefit (p<0.001) and breast cancer-specific survival (p<0.001). Age at diagnosis, race, differentiation grade, T stage, N stage, molecular subtype, metastatic sites, chemotherapy and radiation were associated with overall survival of patients among the surgery cohort. A prediction model was developed based on these factors and had been validated in an independent dataset. The model identified a subset of patients with remarkable survival and a subset of patients who would benefit from the primary tumor surgery.

Conclusions: we have developed a predictive model to identify patients that will achieve long-term survival benefit from primary tumor surgery. This model will provide guidance to physicians considering whether to conduct a primary tumor surgery for female patients with metastatic breast cancer.