Cohen-Armon
Tel-Aviv University, Israel
Title: Exclusive self-destruction of triple negative breast cancer cells
Biography
Biography: Cohen-Armon
Abstract
A newly - discovered mechanism involves the modification of specific proteins that affect the construction and stability of the spindle structure during mitosis. Their exclusive modification in human cancer cells prevented chromosomes segregation into daughter cells. Modifications of kinesins and NuMA, preventing their normal activity in the spindle of human cancer cells disrupted chromosomes alignment in the spindle mid-zone. This induces a rapid cell self-destruction while mitosis is prevented. Thus, the faster the cancer cells proliferate, the more quickly they die. Research was conducted using both cancer cell cultures and mice transplanted with human cancer cells. Mice transplanted with triple negative breast cancer cells revealed the arrest of tumor growth by agents causing their exclusive cell-death during mitosis, without affecting normal proliferating cells.