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4th World Congress on Breast Cancer

Singapore City, singapore

Sudhakar Jha


Sudhakar Jha

National University of Singapore, Singapore

Biography

Sudhakar Jha’s group is interested in understanding the regulation of chromatin remodeling complexes and their role in cancer prevention and intervention. Chromatin remodeling complexes play an important role in maintaining chromatin organization as they create a histone code that is read by specific readers resulting in an active or repressed chromatin. Dr. Jha’s group has purified and characterized chromatin-remodeling complexes implicated in transcription and DNA damage response (Mol Cell 2009, 34: 521-533). Dr. Jha’s group has identified the role of TIP60, a histone acetyltransferase in DNA damage response pathway (Mol Cell Biol 2008, 28: 2690-2700) and RVB1, a component of TIP60 complexes to be required for activity of this complex (Mol Cell Biol 2013, 33: 1164-74). Following which, his group has discovered Human Papillomavirus (HPV) E6 and Adenovirus (AdV) oncogenes to destabilize TIP60 (Mol Cell 2010, 38: 700-711; Oncogene 2013, 32: 5017-25 and Oncogene 2016, 35:2062- 74). Dr. Jha’s have recently identified and new cellular regulator of TIP60 and have demonstrated its role and significance in epithelial-mesenchymal transition and breast cancer progression (Oncotarget 2015, 6:41290-306 and J Mol Cell Biol 2016, 85: 384–399).
csisjha@nus.edu.sg

Abstract

Abstract : TIP60 inhibits epithelial-mesenchymal transition program in breast cancer: A HAT with many tricks