Ellie Wright
Southwest College of Naturopathic Medicine, USA
Title: Punica grantum role in breast cancer prevention and suppression
Biography
Biography: Ellie Wright
Abstract
The new studies shows exciting results in anti tumoral properties of Punica Grantum. The components of Punica Grantum are ellagic acid, ellagitannins (including punicalagins and punicalin) punicic acid, flavonoids, anthrocyanidins, anthorcyanis, estrogenic flavonols and flavons. Punicalgin can be found in seeds, peels juice of pomegranate. Both punicalgin and punicalin can be hydrolyzed to ellagic acid, a natural phenol. Pomegranate juice is rich in polyphenols, tannins, anthocyannins, includind vit C, vit E, co Q10 and lipoic acid. The synergisitic effect of all these components is superior than each individual constituents. The ellagic acid induces cell cycle arrest and apoptosis through TGF-B pathway in human breast cancer MCF- 7 cells. Pomegranate extract reduces the production of vascular endothelial growth factor (VEGF). Pomegranates extracts ellagitannins and punicalagin directly suppress inflammatory cell signaling, inhibits cytochrome P450 enzyme lowering the risk of cancer, inhibits production of VEGF while upregulating production of migratory inhibitory factor (MIF). Punic acid is omega 5 polyunsaturated fatty acid that inhibits both estrogen dependent and estrogen independent breast cancer cell proliferation in lab. Pomegranate ellagitannin-derived compounds exhibit antiaromatase activity and affect the growth of breast cancer cells. Βeta-sitosterol (β-SITO), a phytosterol present in pomegranate is a potent anticancer compound that interferes with microtubule.