10^th World Congress on Breast Cancer April 20-21, 2020 Berlin, Germany

Over the past 40 years, breast cancer treatment has greatly improved due to lessons learned through clinical trials. Clinical trials test the safety and benefits of new treatments as well as new combinations (or new doses) of standard treatments. They can also study other parts of care including risk reduction, diagnosis and screening. People volunteer to take part in clinical trials. Those who join help further the knowledge base that helps improve breast cancer care.

Though death rates have been decreased since 1989, about 40,610 women are expected to die in the year 2017 in the U.S. from breast cancer. Women under the age of 50 have experienced larger decreases. These decreases are thought to be the result of treatment advances, earlier detection through screening and increased awareness. Besides skin cancer, breast cancer is the most commonly diagnosed cancer among American women. In 2017, it is estimated that about 30% of new cases diagnosed in women will be breast cancers.

Breast cancer is more common in African-American women than in white women under the age 45. Overall, African-American women are more likely to die of breast cancer. For Asian, Hispanic and Native-American women, the risk of developing and dying from breast cancer is lower. As many as 40 % cases more cases are predicted by 2030.

A case study is a research strategy and an empirical inquiry that investigates a phenomenon within its real-life context. Case studies are based on an in-depth investigation of a single individual, group or event to explore the causes of underlying principles.

Breast Cancer 2020 Conference aims to bring together the Professors, Researchers, scientists, business giants and technocrats to provide an international forum for the dissemination of original research results, new ideas and practical development and discover advances in health practice, management and education in relation to health disparities as well as a breadth of other topics.

In addition to exciting technical symposia, tutorials, industry panels and exhibitions, Breast Cancer 2020 Breast Cancer 2020 Conference aims to bring together the Professors, Researchers, scientists, business giants and technocrats to provide an international forum for the dissemination of original research results, new ideas and practical development and discover advances in health practice, management and education in relation to health disparities as well as a breadth of other topics.

According to the studies combination of factors are responsible for breast cancer risk. The main factor is age, most of the breast cancer cases noticed in women with age 50 or older, Genetic mutations are also risk factor behind breast cancer. Mutations in certain genes like BRCA1 and BRCA2 can go from one generation to other generation and it can increase the risk of breast cancer.

A healthy diet and maintaining weight can reduce the risk of breast cancer. Smoking during early adulthood and adolescence can increase the risk of breast cancer in the latter stage of life. Eating plant-based food and reducing the alcohol consumption helps in prevention of Breast Cancer. Physical activities particularly after menopause like cycling, walking, playing with children helps in reducing the risk of breast cancer. Breastfeeding also reduces the risk of breast cancer. Hormone replacement therapy, use the contraceptive pill can increase the menace of breast cancer. Pregnancy also affects breast cancer; women who are starting their family early are at lower breast cancer risk than the women who are giving birth at a late age.

Mammograms can help in saving lives by detecting breast cancer early. The women who are not having any sign and symptoms of breast cancer can also go for mammography, this is known as a primary mammogram. During screening mammogram, two or more X-rays pictures are taken of each breast. Microcalcification can be detecting using screening mammography that indicates the presence of Breast Cancer. A diagnostic mammogram can be used after screening mammogram to investigate the symptoms in details that are detected in screening mammogram. Mammography related controversies are also there because of False-positive results, over diagnosis, and overtreatment, False-negative results, Radiation exposure, etc. Screening mammogram and Diagnostic mammogram

One of the most aggressive types of breast cancer occurring in women of any age is inflammatory breast cancer. The typical presentation is rapid swelling, sometimes associated with skin changes, persistent itching rapid increase in breast size, redness and nipple retraction. It is often regarded as systemic cancer. Breast cancer is diagnosed by a biopsy where it confirms as malignancy Ultrasound is useful for looking at some breast changes, such as lumps or changes in women with dense breast tissue especially those that can be felt but not seen on a mammogram that are best breast cancer screening tests. All Inflammatory breast cancers start as Stage IIIB since they involve the skin but if cancer has spread to lymph nodes around the collarbone or inside the chest, its stage IIIC and cancer that has spread outside the breast and nearby lymph nodes it is stage IV.

Breast cancer staging describes how much cancer is in the body which is treated with chemotherapy, hormone therapy, and drugs. It has both medical and pathologic staging systems for breast cancer. The pathologic stage also called the medical stage is determined by examining tissue removed during an operation. If surgery is not conceivable, sometimes right away cancer will be given a clinical stage instead. Imaging tests like x-rays, CT scans, MRIs, ultrasound, and PET scans may also give information about how much and where cancer is in the body. In the system called TNM, every cancer is assigned a letter or number to describe the tumor, node, and metastases. T stands for the original tumor, where T category gives information about aspects of the original (primary) tumor, such as its size whether it has grown into nearby tissues. N stands for nodes where category describes whether cancer has spread into nearby lymph nodes and M stands for metastasis in which this category tells whether cancer has spread to distant parts of the body. In stage grouping, once the values for T, N, and M have been determined, they are combined to assign an overall stage.

Breast cancer management takes different approaches that depend on the physical and biological characteristics of the disease, age, overall health and personal preferences of the patient. There are 2 types of treatment classified into local therapy (surgery and radiotherapy) and systemic treatment (chemo-, endocrine, and targeted therapies). The mainstay of breast cancer management is surgery for the local and regional tumor, followed by a combination of chemotherapy, radiotherapy, endocrine therapy, and targeted therapy. Radiation treatment includes utilizing high-vitality X-rays or Gamma rays that target a tumor or post-surgery tumor site. Cryoablation trial treatments accessible for women with small or early-stage breast cancer. The rejuvenation of the breast after breast cancer surgery is included in holistic approaches to cancer management to address identity and expressive aspects of the disease whereas reconstruction can take place at the same time as cancer-removing surgery, takes to an inordinate length of time later so some women decide not to have reconstruction and they opt for a prosthesis instead. Epidemiologic risk factors vary by the hormone receptor expression of the breast cancer divided into preventable and non-preventable. Their study belongs in the field of epidemiology.

Nurses play an important role during the treatment of breast cancer because they can help the patient to build physically and mentally. They can educate patients about risk factors, ways to reduce them. Nurses involved in breast cancer care have an impact on the early discovery of breast cancer, treatment, and they serve as advocates for women with the disease.

Immunotherapy improves the aftereffect of clinical treatment in breast cancer patients. Targeted treatment is the approach used to directly target tumor cells, side effects of immunotherapy can be decreased.

Cancer cells are very complex cells and it is challenging for clinicians to manage breast cancer therapy. Tumor cells are having different phenotypes and deregulated apoptotic and these characteristics are responsible for improper therapeutic response. For multidrug resistance events major role is played by membrane transporters, they are the cell’s first line of contact with anticancer drugs. So cell structure and biological properties of the cell leads to drug-resistant and lead to a decrease in the intracellular activity of drugs. Breast growth is regulated by the interaction between hormones and growth factors. Genetic changes in growth factor can lead to abnormalities. The immune system of host play a substantial role during breast cancer, breast cancer is a complex disease.

Men are having a small amount of breast tissue, during puberty in girls tissue grow and develops but in men, it doesn’t. As breast tissue is there in men additionally, they can also get breast cancer like in women. Most of the men are not aware of this and the treatment of breast cancer males is mostly delayed as compared to females because of unawareness. So many things are there that raise breast cancer in men like if any female in the family or close relative is having cancer, radiation exposure to the chest, Klinefelter's syndrome, etc. Symptoms of breast cancer are the same in men like women. Awareness should be there so that we can save our lives.

Most of the women suffering from breast cancer have to face breast surgery as a part of treatment. Different ins and outs are there due to which breast surgery is done: to remove cancer cells consist of breast-conserving surgery and mastectomy, to find whether cancer is spreading or spread already including a biopsy or axillary lymph node dissection, after removal of cancer for resorting the shape of the breast that is breast reconstruction. Surgery side effects are there.

Early detection is always better and can be done through screening methods. If family history is there for breast cancer, then one should go for the advice of a doctor. Screening methods are medical breast examination (doctors or nurses examine women's breasts for lumps), mammography, and other imaging techniques. If the lump is there in the breast it can be breast cancer. X-rays are taken to closely observe the breast cancer which is known as a mammogram. After lump detection or other sign mammogram is used.

Breast cancer advocacy and awareness efforts are a type of advocacy. Breast cancer consciousness is an effort to raise awareness and reduce the stigma of breast cancer through education on symptoms and treatment whereas breast cancer advocates raise funds for more patient empowerment, better care, more knowledge, and by conducting educational campaigns or providing free or low-cost services. Breast cancer culture, at times called pink ribbon culture, the outgrowth of breast cancer advocacy, is the social movement that supports the larger women's health movement, socially aware, pro-woman individuals, businesses and governments to signal their support for women, health, and mainstream medicine. The environmental breast cancer drive suspects pollution as a substantial cause, possibly from pesticides, plastics, and industrial runoff in groundwater.