Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 4th World Congress on Breast Cancer Holiday Inn Atrium, Singapore.

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Day 1 :

Keynote Forum

Sudhakar Jha

National University of Singapore, Singapore

Keynote: TIP60 inhibits epithelial-mesenchymal transition program in breast cancer: A HAT with many tricks

Time : 10:00-10:40

Breast Cancer Summit 2017 International Conference Keynote Speaker Sudhakar Jha photo
Biography:

Sudhakar Jha’s group is interested in understanding the regulation of chromatin remodeling complexes and their role in cancer prevention and intervention. Chromatin remodeling complexes play an important role in maintaining chromatin organization as they create a histone code that is read by specific readers resulting in an active or repressed chromatin. Dr. Jha’s group has purified and characterized chromatin-remodeling complexes implicated in transcription and DNA damage response (Mol Cell 2009, 34: 521-533). Dr. Jha’s group has identified the role of TIP60, a histone acetyltransferase in DNA damage response pathway (Mol Cell Biol 2008, 28: 2690-2700) and RVB1, a component of TIP60 complexes to be required for activity of this complex (Mol Cell Biol 2013, 33: 1164-74). Following which, his group has discovered Human Papillomavirus (HPV) E6 and Adenovirus (AdV) oncogenes to destabilize TIP60 (Mol Cell 2010, 38: 700-711; Oncogene 2013, 32: 5017-25 and Oncogene 2016, 35:2062- 74). Dr. Jha’s have recently identified and new cellular regulator of TIP60 and have demonstrated its role and significance in epithelial-mesenchymal transition and breast cancer progression (Oncotarget 2015, 6:41290-306 and J Mol Cell Biol 2016, 85: 384–399).
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Abstract:

HIV-Tat-interacting protein 60 KDa (TIP60) is a lysine acetyltransferase implicated in transcription, DNA damage response and apoptosis. It is known to be downregulated in multiple cancers. Recent studies have shown that TIP60 downregulation correlates with node positivity, metastasis and poor survival rate. Epithelial-mesenchymal transition (EMT) is considered as an important step in cancer metastasis. During this process, there is an overexpression of EMT inducers such as Snail2 (also known as Slug) and repression of cell adhesion molecules such as E-cadherin and EpCAM. Additionally, previous report has demonstrated that E-cadherin and EpCAM expression were repressed by DNA hypermethylation on their promoter region during EMT. In this conference, I will be discussing data that show TIP60 expression partially abrogates cell migration and metastatic potential of breast cancer cells both in vitro and in vivo models. Mechanistically, we show this is through its ability to destabilize DNMT1 and inhibit Snail2 expression. Depletion of TIP60 stabilizes DNMT1 and increase Snail2 level, resulting in the EMT. Activation of DNMT1-Snail2 axis in the absence of TIP60 represses expression of epithelial markers by increased DNA methylation on their promoter region. In pathophysiological scenario, we find TIP60 to be significantly downregulated in breast cancer patients with poor Overall Survival (OS) and Disease-Free Survival (DFS) prognoses. These data suggest that levels of TIP60 can be a prognostic marker of disease progression and stabilization of TIP60 could be a promising strategy to treat cancers.

Keynote Forum

Wang Xuefei

Peking Union Medical College Hospital, China

Keynote: CTC immune escape mediated by PD-L1
Breast Cancer Summit 2017 International Conference Keynote Speaker Wang Xuefei photo
Biography:

Wang Xuefei is a Medicine Doctor graduated from PUMCH (Peking Union Medical College and Hospital). Currently, she is the fellow of the breast surgery department in PUMCH. She is also a member of Beijing Breast Disease Society of Young Academic. These years, her researches are focused on metastatic breast cancer, especially on CTC of breast cancer. She has also obtained the patent of CTC hemodialysis, meanwhile, participated in a number of national projects, including Beijing Municipal Science and Technology project, National 11th Five-Year issue, National 12th Five-Year issue. She has published more than 14 articles and books, including 4 SCI articles, and did oral and poster presentation in many breast cancer related conferences.

Abstract:

Breast cancer is the most common malignant tumor in women around the world. CTC (circulating tumor cell) is associated with the breast cancer patients’ cancer-related deaths and prognosis. The recently circulating clusters were found and its metastasis and tumor formation ability is 23~50 times as CTC. However, its mechanism has not been clarified. These days, researchers have successfully completed CTC cluster separation, CTC cell culture, and PD-L1 was found to be related with histological grading of tumor. Meanwhile, the high expression of PD-L1 in CTC surface has also been reported. Since PDL1 can mediate Treg to play the role of immunosuppression, we propose that CTC with positive PD-L1 is easier to connect PD-L1, immune cells and CK cytokines etc. Treg cells can protect CTC from being attacked by the immune system through the immunosuppression. Meanwhile, they can weaken CTL killing ability and trigger more MDSC. Finally, CTC formed the metastasis. To explore this hypothesis we have analyzed CTC and PD-L1 mRNA expression on CTC in 10 metastatic breast cancer patients and 10 primary breast cancer patients. We have also analyzed the relationship between clinical pathological features and PD-L1 expression on CTC, through overall and split chi square test. The results show that in the total 20 patients, 15 have more than 1 CTC in 7.5 ml peripheral blood. Among the 15 patients, each one has at least 1 CTC showing PD-L1. We found PD-L1 on CTC is related to the tumor size (P=0.012) lymph node status (P=0.001) and PR status (P=0.037). In tumor size group, we can see statistical difference between T2 and T3 (P=0.003), while in node status group statistical difference can be found in N1 vs. N3 (P=0.000) and N2 vs. N3 (P=0.015). However, we didn’t see difference of PD-L1 on CTC in metastatic and non-metastatic patients (P=0.418). Next, we are preparing for the cell experiment to further discover it.

Break: Networking & Refreshments Break @ Pre Function Area 11:20-11:40
  • Causes of Breast Cancer | Prevention of Breast Cancer | Treatments of Breast Cancer | Chemotherapy | Breast Cancer-Present Perspective
Biography:

Vetty Priscilla got her master degree and nursing specialist in University of Indonesia and Master of public Health in Amsterdam. She is a lecturer and researcher in Faculty of Nursing, Andalas University Indonesia. Thus, she is also a clinical instructor in the teaching hospital and also takes a role in caring patient as a clinical care manager. Mostly, she has concern on the maternity problem and Women’s Health.

Abstract:

Statement of the Problem: Breast cancer is the highest rates and one of the main causes of death for women. Many therapies have used as the treatments for breast cancer, and one of them is chemotherapy. Breast cancer chemotherapy patients have high risk for stress not only because of the disease itself but also the side effects of chemotherapy. Researchers have reported about related factors with stress in breast cancer chemotherapy patients, but no one has studied about related factors with stress in Minangnese patients. Minangkabau is an ethnic place where women’s position is very special and highly respected by others. The purpose of this study was to determine stress of breast cancer chemotherapy among Minangnese patients and its influencing factors in public Hospital of Padang.
Methodology: This study was descriptive correlation with cross sectional approach.
Findings: Samples of this study were 85 respondents with accidental sampling technique. This study was conducted in a public Hospital of Padang on May until August, 2016. The study instruments were crisis oriented personal scale (Copes) and depression anxiety and stress scale (DASS).
Conclusion & Significance: The bivariate data were analyzed by Pearson Product Moment test, T test, Annova and the multivariate data were analyzed by multiple linear regression test. The result showed that the characteristics of age, length of time since diagnosis of cancer and undergoing chemotherapy, looking for social and spiritual support had a significant relationship with the stress experienced for breast cancer chemotherapy patients. The most dominant factor influencing stress for breast cancer patient was looking for social support recommended for the patients to make a peer group to giving social support by using social media.

Speaker
Biography:

Ivan Terziev was born in 1961. He graduated in Medicine in 1987 from the Medical University of Sofia and obtained a specialty in Pathology and Cytology in 1991. Dr Terziev has been working at Tsaritsa Yoanna ISUL University Hospital since 1988, and he is also an Assistant professor of Pathology at the Medical University of Sofia, Bulgaria. Dr Terziev is a member of Bulgarian and European Society of Pathology and Bulgarian-Turkish group on Diseases of Thyroid and Breast. He has numerous publications in Bulgarian scientific journals, as well as more than 20 papers in reputed international ones. Dr Terziev is working in the area of histopathology of head of neck, thyroid gland, gastrointestinal, breast and surgical pathology.

Abstract:

Introduction: The incidence of breast cancer (BC) in Bulgaria is lower than the average in Europe (76.3 out of 100 000 females to average in Europe 94.2/100 000 females). The data from Bulgarian National Cancer Registry for the last 40 years shows continuous growth in the number of newly diagnosed cases – from 1632 patients in 1976 to 4000 in 2014. The staging distribution for 2013 is the
following: stage I (A, B) – 29%, stage II (A, B) – 42 %, stage III (A, B, C) – 20 %, stage IV – 5 %, unclassified – 4 %1.
Purpose: The purpose of this study is to analyze the choice of therapeutic management in patients with BC, diagnosed and treated at the Breast Unit, University Hospital ''Tzaritza Joanna – ISUL'', Medical University (MU) of Sofia in 2016 according to the stage of the disease.
Materials and method: All patients, diagnosed with BC were staged according to the TNM- classification (8th edition). The University
of Southern California/Van Nuys Prognostic Index (USC/VNPI), the Memorial Sloan-Kettering Cancer Center (MSKCC) nomogram and Medical University Sofia (MUS) prognostic model for evaluating the probability of local recurrence were used in determining the treatment options for patients with non-invasive form of BC (DCIS)2. The selection of patients with early breast cancer, suitable for breast-conserving surgery (BCS) with simultaneous intraoperative radiotherapy (IORT), was accomplished according to The Groupe Européen de Curiethérapie-European Society for Therapeutic Radiology and Oncology (GEC-ESTRO) Breast Cancer Working Group (2009) criteria3. SPECT/CT was the preferred method for a preoperative maping of sentinel lymph nodes, followed by intraoperative detection with Europad Gamma Probe camera. We used the INTRABEAM® system (Carl Zeiss Surgical Gmbh, Oberkochen, Germany) to complete the process.
Results: In 2016 386 BC patients were treated at our Breast Unit. The mean age of the group of 136 newly diagnosed cases (132 females and 5 males) is 59,2 (29-91). Invasive ductal carcinoma was the most frequent finding (76%) and invasive lobular carcinoma occurs in 16 % of all cases. We had one male patient with malignant fibrous histiocytoma of the breast.
Conclusion: Important factors for successful results are the modern complex treatment, which requires individualized approach, and the consequtive modules in standard limits that we provide. The role and advantages of the specialized structures (Breast Units) are undeniable, since they ensure the highest level of diagnosis and treatment, i.e. for the past year at our Breast Unit newly-diagnosed patients were 33% without a single patient with unclear stage. Nationally these numbers are 29% and 4%, respectively.

Break: Lunch Break @ Pre Function Area 12:40-13:40
Speaker
Biography:

Ns Rika Fatmadona, MKep, Sp.Kep MB, has her expertise in oncology nursing and passion in improving nursing education and health. She has get master and nursing specialist in Oncology at University of Indonesia. Now she works as a lecturer in Nursing Faculty at Andalas University Padang. Her concerned on nursning education, and doing research on cancer patient. Not only that, she is also as a clinical instructor in educational hospital, RSP Andalas Padang and also takes a role in caring patient as a clinical care manager. As a researcher, she is concerned on caring of cancer patient and its impact on family.trying to arrange develop research on her way to get PhD. Her vision in updating knowledge and skill is one way to develop herself. Being good and useful to everyone, is her motto.

Abstract:

Minangnese, community in west sumatera, is the largest matrilineal society in the world, with property, family name and land passing down from mother to daughter. Being diagnosed by Breast cancer (BC) has impact on family integrity, which is a very stressful event for patients and their families. Moreover, The role of the family as significant person and very important in supporting the patient. The research design used was cross sectional with sampling purposive sampling technique. Data collection was conducted from 7 to 16 of December 2015, with 40 people sampled in population of BC patients in public hospital Solok. The aim of this study was to determine the relationship between family support with the quality of life of breast cancer patients in public hospital Solok. Methodology & Theoretical Orientation: This research using corelatic anlysis that discusses the degree of relationship between two variables vary consistently;independent variables (family support) and dependent variable (QoL) in patients with BC in cross-sectional approach. Data were collected through interview using a questionnaire which is processed and analyzed by chisquare test. Findings :The result showed more than half of respondents had negative quality of life in highly support in family. There is a relationship between family support and quality of life.Being diagnosis has been shown to evoke a state of shock, fear and disbelief, thus creating not only a psychological crisis but an existential one as well. Most Minangnese women experience at least some psychosocial distress during the course of their breast cancer diagnosis, but they try to struggle by their own power, keep doing their daily task, until the stadium of BC or its complication make them suffering, and these maketheirqualityof life negative.The level of distress varies from woman to woman and can vary for the individual patient over the course of diagnosis. Recommendations are made for health service to promote early detection of BC and give health education to patient and family of BC

Speaker
Biography:

Ziba Farajzadegan has completed her MD from Tabriz University and specialy studies from Isfahan University School of Medicine. She is working as a preventive Medicine Specialist in Isfahan Medical Sciences for 15 years. Her research interest is women health, focusing on supportive care of women with breast cancer.

Abstract:

Background: Breast cancer is the most common cancer among Iranian women. Breast cancer screening methods have led to earlier diagnosis and improvement in the survival of breast cancer patients. However, Iranian women with a family history of breast cancer are less likely to participate in breast cancer screening programs. In this study we have evaluated the effectiveness of peer group based intervention in promoting breast cancer screening participation in women with a family history of breast cancer.
Method: Women with a family history of breast cancer who were 20 years or older and in pre contemplation, contemplation, or relapse stage of breast cancer screening according to Trans Theoretical Model (TTM) were included. A computerized randomization was performed to allocate participants to the intervention or the control group. In order to prepare peer group leaders, an educational program was held for volunteer women by a health expert. Afterwards, three sessions were held in three weeks for the intervention
group. A questionnaire was filled out for participants in both groups at baseline one and three months after the intervention.
Results: Overall 98 women completed the study. ANOVA showed that one and three months after the intervention, women in the intervention group had a significantly higher level of knowledge, perceived sensitivity, perceived severity, health motivation, CBE and mammography benefits and lower barriers toward CBE and mammography.
Discussion: A structured intervention based on peer group can successfully improve participants’ knowledge, beliefs and participation in breast cancer screening programs in high risk women for breast cancer.

Speaker
Biography:

Fu Zhuo-Han Marc : After a Master in biomedical engineering at UCL. He is currently Business Developer at OncoDNA. It is an exciting challenge to combine
scientific and sales knowledge to further develop OncoDNA’s activities in South East Asian Regions.

Abstract:

Statement of the Problem: Breast cancer (BC) is the most common cancer amongst women in Europe, with one out of eight developing this disease during her lifetime. In the last few decades, surgical excision followed by adjuvant radiotherapy, sentinel lymph node dissection, and adjuvant systemic therapy in the form of chemotherapy, hormonal therapy and Trastuzumab have improved the quality of life and long‐term survival of women diagnosed with early disease. However, BC remains the leading cause of female cancer-related death worldwide. Thanks to the NGS and other tests (like IHCs, methylation), it is now possible to perform a profiling of the tumor to identify either treatments that might be associated with some clinical benefit or resistance to approved treatment.
Methodology: Biopsies of women affected by different breast cancer type have been analysed by sequencing and some specific tests (methylation, IHCs).
Findings: Overall, the NGS provided the oncologist with no use in 50% to 90% of the cases whereas the IHCs/specific tests increase this number by a factor 2 with the caviar of the combination of both. These results were prospectively compared to the decision of the oncologists in an automated way. 23.2% of the patients passed away before the oncologist’s decision. Among the 76.8% remaining, 59.7% followed our recommendations, 27.5% didn’t and 3.1% went against. Only in 6.6% of the cases, the decision was taken according to the NGS only, and 95.4% remaining concerned chemotherapies only. And in 100% of the cases, the treatment chosen was either a drug approved for the cancer type analysed or approved for another cancer type. None of the drugs in development in clinical trial was chosen and only 1% went into a clinical trial.
Conclusion & Significance: This study demonstrated how simple strategies based on the NGS only have a limited impact on the oncologist’s final decision confronted to the reality where only chemotherapies are available in their countries and clinical trials are either not recruiting or really difficult to get into.

Lai Oi Ling

University of the West of England, UK

Title: The Buddhist coping experience of breast cancer survivors: A phenomenological approach

Time : 15:10-15:40

Speaker
Biography:

Lai Oi Ling has done her professional Doctorate in the year 2012 from the University of the West of England. She is the Registered Nurse in Hospital Authority and a member of the Hong Kong Soka Gakkai International. She is actively participating in the Hong Kong Cancer Fund as a Volunteer Lecturer in patient education.

Abstract:

Aim: To be or not to be a breast cancer survivor? This study aimed to explore the spiritual impact of the Buddhist beliefs as a lived experience on breast cancer survivorship in Hong Kong culture.
Method: A phenomenological research design guided in data collection. A purposive sample of ten breast cancer survivors coming from the Soka Gakkai International, Fo Guang Shan was interviewed two times. Twenty semi structured, in-depth and face to face interviews are conducted in the community. All of them recites the Buddhist Sutra and perform different meditation practices every day. Their unique lifeworld stories reflected on the Hong Kong healthcare context. Two layers data reduction included the thematic analysis and the van Manen's method. The researcher conceptualized themes under the lived space, lived body, lived time, and lived human relations. The hermeneutics approach elaborated the participant's life including being, being-with-others, and being-in-the-world.
Result: These women expressed that the Buddhist mindfulness and chanting meditation have led them to be open and to accept all experiences in their way. The survivors perceived breast cancer as an opportunity to discover their own Buddhahood no matter what difficulties they encountered. Two significant stresses came from the suffering during the treatment and fulfilling the role as a mother. Four Buddhist coping themes were (a) transforming their negative karma, (b) opening up own Buddhahood, (c) fulfilling the Bodhisattvas identity, and (d) hope and future. All of them had performed two patterns including "to actualize their essence of life" and "to study and practice their Buddhist faith." Body and mind changed from passive, "being help by others" to active, "to empower and encourage other people."
Conclusion: Searching the meaning of life is important to help them cope with the adversity in living with cancer. The author suggests the cancer survivors define the ultimate goal in life and explore the significance of faith which empowers them to achieve happiness in their unique way.

Break: Networking & Refreshments Break @ Pre Function Area 15:40-16:00